Intracytoplasmic Sperm Injection (ICSI)

Intracytoplasmic Sperm Injection (ICSI)

Potential parents who’ve been disappointed by failed fertility treatments might have better outcomes with Intracytoplasmic Sperm Injection (ICSI). ICSI is used along with traditional in vitro fertilization (IVF). A woman’s eggs are combined with sperm in a laboratory setting, and the resulting embryo is implanted back into the uterus. The ICSI procedure involves inserting a single sperm into each egg, eliminating sperm penetration during fertilization.

When is ICSI Used?

Certain circumstances might require ICSI in conjunction with IVF. Intracytoplasmic sperm injection is typically used for couples who have attempted conception with no results due to male infertility problems. If your reproductive endocrinologist concludes that fertilization using other methodologies would be insufficient, ICSI IVF might be a viable solution.

Candidates for this treatment include:

  • Males with low sperm count or poor sperm motility (movement)
  • Males with abnormally shaped sperm
  • Males who have had an unsuccessful vasectomy reversal
  • Couples with advanced maternal age
  • Women with diminished ovarian reserve

If the male partner’s sperm count is low or has poor sperm motility, the sperm can be accessed through standard ejaculation. However, suppose the sperm count is extremely low or nonexistent due to vasectomy. In that case, the male can opt for sperm retrieval using needle aspiration, which is the most efficient strategy for collecting sufficient sperm for the treatment. The process involves inserting an extremely thin needle directly into the testis, from which the sperm are extracted. They are then centrifuged to isolate the stronger, more active sperm that are less likely to exhibit malformations.

Fertility medications are administered orally or via injection to the female partner to accelerate ovulation and access mature eggs in preparation for IVF. The resulting eggs are collected using an ultrasound-guided tool. The quality of the extracted eggs is observed and assessed before the procedure.

After the fertilization has been established, the embryo is transferred into the uterine cavity. From there, the patient is observed for signs of pregnancy.

ICSI IVF has been shown to deliver successful outcomes for patients for whom other fertilization efforts have failed. While male infertility is one of the main reasons ICSI protocols are employed, the procedure could help overcome other fertility conditions. These include previously unsuccessful IVF treatments and atypical or unexplained infertility issues. Often, couples opt for ICSI as a fail-safe even when other procedures haven’t been attempted.

Success rates for ICSI are generally very high. Pregnancies achieved using this treatment option are roughly equivalent to those using IVF, where male subfertility is not a contributor.

The fertility specialists at PRC have helped hundreds of patients welcome healthy babies after ICSI treatments. We have enjoyed exceptionally high success rates with this procedure in large part due to our state-of-the-art on-site laboratory. This allows the micromanipulation process to begin immediately to ensure the health and integrity of the embryos are not compromised due to transfer to outside facilities.

Your doctor can help you understand if ICSI is right for you.


Pacific Reproductive Center has been successfully aiding conception for over two decades. We optimize the conditions of fertility treatment to give every potential parent the greatest chance of successful childbirth.


We ensure that every patient fully understands their medical condition and treatment options available to them. We understand each patient is unique so we help guide you through the best option to support your own fertility journey.

Visit Pacific Reproductive Center

Pacific Reproductive Center® is a world-class fertility center in Southern California. With more than 70 years of collective reproductive clinic experience diagnosing and treating infertility, PRC is a leading provider of IVF and fertility care.

PRC is easily accessible whether traveling from local communities including Los Angeles, Orange County, Riverside or points slightly further including San Diego, Temecula, Inland Empire and La Jolla

PRC Torrance
3720 Lomita Blvd, Suite 200 Torrance, CA 90505
Monday – Saturday: 8am – 5pm
Sunday: Closed
PRC Glendale
116 E. Broadway, Suite 300 Glendale, CA 91205
Monday – Friday: 8am – 5pm
Saturday – Sunday: Closed
PRC Irvine
10 Post Irvine, CA 92618
Monday – Friday: 8am – 5pm
Saturday – Sunday: Closed
PRC Corona
381 Corporate Terrace Corona, CA 92879
Monday – Friday: 8am – 5pm
Saturday – Sunday: Closed
CALL TODAY! 866-423-2645

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